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以川乌与白芍配伍前后的水煎液分别给小鼠灌胃 ,急性毒性实验结果为 :川乌 L D5 0 16 3.75 7g· kg- 1、乌芍 1∶ 1L D5 0 2 39.332 g· kg- 1 、乌芍 1∶ 2 L D5 0 2 5 0 .380 g· kg- 1 、乌芍 2∶ 1L D5 0 183.189g· kg- 1 ,配伍前后有明显差异 ( P<0 .0 1) ,表明乌芍配伍能降低川乌的毒性 ,但是 ,腹腔注射未出现上述结果。
The mice were intragastrically administrated with decoction before and after compatibility of Radix Angelicae Dahuri and Radix Paeoniae Alba. The acute toxicity test results were as follows: Chuanwu L D5 0 16 3.75 7g· kg-1, Wuyi 1: 1L D5 0 2 39.332 g kg. - 1, Wuyi 1:2 L D5 0 2 5 0 .380 g·kg-1, Wuyi 2: 1L D5 0 183.189g·kg-1, significantly different before and after compatibility (P<0.01), It was shown that compatibility of Chinese wolfberry can reduce the toxicity of Chuanwu, but the above results did not appear in intraperitoneal injection.