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多发性骨髓瘤(multiple myeloma,MM)是一种以恶性浆细胞克隆性增殖为特征,可引起全身多脏器功能损害的血液系统恶性肿瘤。骨病是其主要临床表现之一,包括广泛性骨质疏松、病理性骨折、脊髓压迫、高钙血症以及骨痛等,严重影响患者生存质量及预后,多种因素导致成骨与破骨细胞失衡是其主要病理机制。如骨髓瘤细胞通过增加肿瘤坏死因子相关激活诱导因子(TRANCE)水平,降低
Multiple myeloma (MM) is a hematological malignancy characterized by clonal multiplication of malignant plasma cells that can cause systemic multiple organ dysfunction. Osteopathy is one of its main clinical manifestations, including extensive osteoporosis, pathological fractures, spinal cord compression, hypercalcemia and bone pain, etc., seriously affecting the quality of life and prognosis of patients, a variety of factors lead to osteogenesis and osteoclast Cell imbalance is its main pathological mechanism. Such as myeloma cells by increasing the level of tumor necrosis factor-related inducible factor (TRANCE), decreased