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急性心力衰竭(AHF)是临床常见疾病,因其具有高发病率、高致死率和高致残率而引起广泛关注。松弛素能增加心输出量、降低血管阻力、增加肾小球滤过率和肾血管流量,因此可使AHF患者受益。结合近年来有关松弛素的基础研究,本文总结归纳了松弛素在治疗AHF中的作用及其相关机制,并对松弛素作为一种治疗AHF的新药在前期临床试验中的结果进行简要介绍。
Acute heart failure (AHF) is a common clinical disease, which has aroused widespread concern due to its high morbidity, high mortality and high morbidity. Relaxin can increase cardiac output, reduce vascular resistance, increase glomerular filtration rate and renal vascular flux, which can benefit AHF patients. Based on the basic researches on relaxin in recent years, this paper summarizes the role of relaxin in the treatment of AHF and its related mechanisms, and gives a brief introduction of the results of the preliminary clinical trial of relaxin as a new drug for the treatment of AHF.