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目的:观察比亚芬乳膏防治鼻咽癌同期调强放疗及化疗患者急性放射性皮肤损伤的临床疗效。方法:将51例需要放射治疗的患者随机分为2组,均采用瓦里安600CD含120叶多叶光栅的6MV X线三维适形调强技术照射,并联合卡培他滨同步化疗。25例在第1次放射治疗及化疗后给予比亚芬乳膏涂抹为用药组;26例只做常规放射治疗宣教和健康教育为对照组。结果:两组患者皮肤反应发生率为100%。轻度放射反应(Ⅰ+Ⅱ度):用药组为88.0%(22/25例),对照组为57.7%(15/26例);Ⅲ度放射反应:用药组12.0%(3/25例),对照组42.3%(11/26例)。两组之间有显著差异P<0.01。皮肤反应发生剂量:用药组32.0%(8/25例)、对照组96.2%(25/26例),出现于照射40G y以前。结论:比亚芬能有效地预防鼻咽癌放、化疗同期较严重放射性皮炎的发生,对患者能减轻痛苦、提高生话质量、保证放射治疗的顺利进行。
Objective: To observe the clinical efficacy of biaofen cream in the prevention and treatment of acute radiation-induced skin lesions in patients with nasopharyngeal carcinoma treated by intensity modulated radiation therapy and chemotherapy. Methods: A total of 51 patients undergoing radiotherapy were randomly divided into 2 groups. Both of them were irradiated with Varian 600CD 6-mm X-ray three-dimensional conformal radiofrequency with 120-leaf multi-leaf gratings and combined with capecitabine concurrent chemotherapy. Twenty-five patients were treated with bafufen cream as the medication group after the first radiotherapy and chemotherapy, while only 26 cases were treated by routine radiotherapy and health education as the control group. Results: The skin reaction rate was 100% in both groups. The mild radiation reaction (Ⅰ + Ⅱ degree) was 88.0% (22/25 cases) in the treatment group and 57.7% (15/26 cases) in the control group. The third degree radiation reaction was 12.0% (3/25 cases) , 42.3% (11/26 cases) in the control group. There was a significant difference between the two groups P <0.01. The dose of skin reaction occurred in 32.0% (8/25 cases) in the medication group and 96.2% (25/26 cases) in the control group before the irradiation of 40 Gy. Conclusion: Biafine can effectively prevent radiotherapy and dermatitis of nasopharyngeal carcinoma during the same period of radiotherapy and chemotherapy. It can relieve the pain and improve the quality of the living voice in patients with nasopharyngeal carcinoma and ensure the smooth progress of radiotherapy.