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目的：研究１５肺泡最小浓度（ＭＡＣ）的氟烷和七氟醚对缺血再灌注心肌功能和氧自由基的影响。方法：应用离体大鼠心脏Ｌａｎｇｅｎｄｏｒｆ逆行灌注模型研究１５ＭＡＣ的氟烷、七氟醚对心肌缺血前后心功能的影响，测定缺血前、缺血１０ｍｉｎ、复灌３０ｍｉｎ３个不同时间的心肌超氧化物歧化酶（ＳＯＤ）活性和丙二醛（ＭＤＡ）含量。结果：七氟醚不同程度地抑制心肌收缩功能。缺血１０ｍｉｎ时，七氟醚组ＳＯＤ酶活性明显下降，ＭＤＡ含量显著升高。缺血２５ｍｉｎ复灌３０ｍｉｎ后，二药均能促进心肌功能和ＳＯＤ酶活性恢复，抑制ＭＤＡ生成，其中七氟醚的作用较为明显。结论：二药对缺血再灌注心肌具有一定的保护作用，七氟醚优于氟烷。
Objective: To investigate the effects of halothane and sevoflurane with minimum alveolar concentration of 15 on myocardial function and oxygen free radical in ischemia reperfusion. Methods: Langendorf retrograde perfusion model of isolated rat heart was used to study the influence of 1, 5 MACA halothane and sevoflurane on the cardiac function before and after myocardial ischemia. The myocardium was measured before ischemia, 10 minutes after ischemia and 30 minutes after reperfusion Superoxide dismutase (SOD) activity and malondialdehyde (MDA) content. Results: Sevoflurane inhibited myocardial contractile function to varying degrees. Ischemia 10min, sevoflurane group SOD activity decreased significantly, MDA content was significantly increased. After reperfusion for 30min after ischemia for 25min, both drugs can promote myocardial function and SOD activity recovery, inhibit MDA formation, of which the role of sevoflurane is more obvious. Conclusion: The two drugs have a protective effect on myocardial ischemia-reperfusion injury, sevoflurane is superior to halothane.