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单用5-Fu 治疗晚期结直肠癌和胃腺癌,仅对20%的结直肠癌和25%的胃腺癌患者有短期疗效,且总的存活率未见增加.本试验基于生化和各种细胞株培养的研究证明:加大细胞内叶酸量能使胸腺嘧啶核苷酸合成酶(TS)达到最适抑制怍用,并能增加5-FU 的细胞毒作用.本试验之目的即是5-FU 联用大剂量甲酰
The use of 5-Fu alone in the treatment of advanced colorectal and gastric adenocarcinomas has short-term efficacy in only 20% of colorectal cancers and 25% of gastric adenocarcinomas, and no increase in overall survival. This test is based on biochemistry and various cells. The strain culture study demonstrated that increasing the amount of intracellular folate allows thymidine nucleotide synthetase (TS) to achieve optimal inhibition and increase the cytotoxicity of 5-FU. The purpose of this trial is 5- FU combined with large doses of formyl