论文部分内容阅读
目的探讨蚓激酶对血液流变性异常及甲襞微循环障碍的治疗作用。方法９０例冠心病人随机分两组：治疗组４８例（蚓激酶组），对照组４２例（精制蝮蛇抗栓酶组）。另健康老年人４０例，作正常对照。治疗前后分别检查血液流变学及甲襞微循环。结果两组治疗前后自身对比疗效显著（Ｐ＜０．０１）。两组之间疗效比较，治疗组下降幅度较大，但无显著性差异（Ｐ＞０．０５）。结论蚓激酶治疗老年冠心病伴血液流变性异常及甲襞微循环障碍，效果与蝮蛇抗栓酶组相当，疗效确切、安全，口服简便，更适用于行动不便的老年患者。
Objective To investigate the therapeutic effect of lumbrokinase on abnormal hemorheology and microcirculation of nailfolds. Methods Ninety patients with coronary heart disease were randomly divided into two groups: the treatment group 48 cases (lumbrokinase group), the control group 42 cases (purified viper snake antithrombin group). Another 40 healthy elderly, as a normal control. Hemorheology and nailfold microcirculation were examined before and after treatment. Results The curative effect of the two groups before and after treatment was significant (P <0.01). The curative effect between the two groups was significant, but there was no significant difference (P> 0.05). Conclusion The efficacy of lumbrokinase in the treatment of senile coronary heart disease with hemorrheological abnormalities and microcirculation of formazan is equivalent to that of viper antithrombotic enzyme group. The efficacy, safety and oral administration of lumbrokinase are more suitable for senile patients with mobility impairment.