内源性哇巴因 (EO)是新近发现的一种类固醇激素 ,具有重要的病理和生理学意义。应用细胞培养、离体及在体动物实验的研究结果以及大量的临床证据表明 ,EO可能是由肾上腺皮质分泌的 ,但也有研究提示它可能来源于下丘脑。EO的分泌受摄盐量、血容量、肾素 血管紧张素 醛固酮系统、中枢神经系统、体内胰岛素水平以及缺氧等多种因素的调节 ,对机体水、电解质平衡的稳定以及血压调控等方面具有重要作用。 Endogenous ouabain (EO) is a newly discovered steroid hormone, has important pathological and physiological significance. The application of cell culture, in vitro and in vivo animal studies, as well as a large number of clinical evidence that EO may be secreted by the adrenal cortex, but there are studies suggest that it may originate from the hypothalamus. EO secretion by the salt intake, blood volume, renin angiotensin aldosterone system, the central nervous system, insulin levels and hypoxia and other factors in the regulation of the body’s water and electrolyte balance and stability and blood pressure control and so on Important role.