目的　为了引起广大医务人员对难辨梭菌引起抗生素相关性腹泻高度的重视 ,以预防院内难辨梭菌性腹泻的发生和暴发流行。方法　对 1999年上半年内外科发生的两例难辨梭菌引起的腹泻进行分析。结果　难辨梭菌性腹泻可由广谱抗生素的应用、外科手术、白血病、抗肿瘤治疗、肠梗阻等因素诱发 ,其治疗方法 ,轻、中度腹泻停用抗生素 ,重症加用甲硝唑或万古霉素和生物制剂。结论　严格控制广谱抗生素的应用 ,保护机体的正常菌群 ,加强患者消毒隔离、医护人员严格洗手是预防传播的重要措施 Objective In order to arouse the majority of medical staff on the Clostridium difficile caused by antibiotic-associated diarrhea, a high degree of attention to prevent Clostridium difficile diarrhea hospital outbreaks and outbreaks. Methods Two cases of Clostridium difficile-induced diarrhea in surgery and surgery in the first half of 1999 were analyzed. Results Clostridium difficile diarrhea can be broad-spectrum antibiotics, surgery, leukemia, anti-tumor therapy, intestinal obstruction and other factors induced by the treatment of light and moderate diarrhea with antibiotics, severe plus metronidazole or eternal Mycotoxin and biological agents. Conclusion Strict control of the application of broad-spectrum antibiotics, to protect the normal flora of the body, to strengthen the disinfection and isolation of patients, strict hand-washing of health care workers is an important measure to prevent transmission