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目的 检测嗜铬粒蛋白Ａ（ＣｇＡ）在前列腺癌组织中的表达。方法 采用免疫组化技术观察ＣｇＡ、神经特异性烯醇化酶（ＮＳＥ）、生长抑素（ＳＳ）及降钙素（ＣＴ）在３０例前列腺癌和２０例前列腺增生症组织中的表达。结果 ＣｇＡ在前列腺癌和前列腺增生症标本中的表达率分别为６０％和２５％，两者有显著性差异（Ｐ＜０．００１）。明显高于生长抑素（ＳＳ）、降钙素（ＣＴ）免疫组化染色和常用的Ｃｒｉｍｅｌｉｕｓ嗜银染色的表达率，与神经特异性烯醇化酶（ＮＳＥ）表达率无显著性差异。结论 ＣｇＡ是前列腺癌组织中ＮＥ细胞最敏感的标记物，ＣｇＡ免疫组化染色可作为检测前列腺癌组织中神经内分泌细胞及分化的一种可靠的方法。
Objective To detect the expression of chromogranin A (CgA) in prostate cancer. Methods Immunohistochemistry was used to observe the expression of CgA, NSE, SS and CT in 30 cases of prostate cancer and 20 cases of benign prostatic hyperplasia. Results The positive rates of CgA expression in prostate cancer and benign prostatic hyperplasia were 60% and 25% respectively, with significant difference (P <0.001). It was significantly higher than that of somatostatin (SS), calcitonin (CT) immunohistochemical staining and the commonly used silver staining of Crimelius. There was no significant difference between the two groups in the expression of neuron specific enolase (NSE). Conclusion CgA is the most sensitive marker of NE in prostate cancer. CgA immunohistochemical staining can be used as a reliable method to detect the differentiation of neuroendocrine cells in prostate cancer tissue.