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目的了解陕西省关中地区健康人群脑膜炎奈瑟菌(Neisseria meningitidis,Nm)的带菌状况,为流行性脑脊髓膜炎(流脑)防治提供依据。方法在西安市和宝鸡市共选择998名健康人群采集咽拭子进行细菌分离培养和PCR核酸检测,并将阳性Nm株进行分群。结果关中地区健康人群Nm总带菌率为6.42%(64/998)。宝鸡市人群Nm带菌率(8.25%)显著高于西安市(4.50%)(χ~2=5.85,P<0.05)。15-24岁年龄组带菌率(13.45%)显著高于0-2岁年龄组(4.71%)(χ~2=7.89,P<0.05)。在64株Nm阳性菌株中,A、B、C和不可分群分别占1.56%、7.81%、25.00%和65.63%。结论关中地区健康人群Nm带菌率总体较低,菌群分布与中国其他地区基本一致。
Objective To understand the carrier status of Neisseria meningitidis (Nm) in Guanzhong area of Shaanxi Province and provide basis for the prevention and treatment of epidemic cerebrospinal meningitis. Methods A total of 998 healthy people in Xi’an and Baoji were enrolled in the throat swabs for bacterial isolation and PCR detection, and the positive Nm strains were clustered. Results The total Nm carrying rate of healthy population in Guanzhong was 6.42% (64/998). The population of Nm in Baoji City was significantly higher than that in Xi’an (8.25%) (4.50%, χ ~ 2 = 5.85, P <0.05). The incidence of infection in the 15-24 age group (13.45%) was significantly higher than that in the 0-2 age group (4.71%) (χ ~ 2 = 7.89, P <0.05). Among 64 Nm positive strains, A, B, C and inseparable group accounted for 1.56%, 7.81%, 25.00% and 65.63% respectively. Conclusion The prevalence of Nm in healthy population in Guanzhong area is generally low, and the distribution of flora is basically consistent with that of other areas in China.