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目的 观察99Tcm 4,9 二氮 3,3,10 ,10 四甲基十二烷 2 ,11 二酮肟 (HL91)在局部脑缺血模型脑组织中分布特点。方法 建立 31只大鼠局部脑缺血模型 ,对99Tcm HL91在正常大鼠体内以及在动物模型脑组织中的分布进行研究 ,同时对动物模型脑组织行放射自显影研究。结果 99Tcm HL91静脉注射后主要分布于肝、肾、小肠 ,正常脑组织放射性较低。患 /健侧大脑中动脉主要供血区(靶区 )单位质量放射性比值与对照组相比差异均有显著性 ,且随时间的延长而逐渐增高。动物模型脑组织自显影图像均可见靶区放射性明显高于对侧镜像部位 ,经计算机图像分析系统进行图像分析和数据处理后 ,同一时相靶与非靶区单位面积净吸光度值差异有显著性 ,各时相靶 /非靶比值与对照组比较差异均有显著性 ,且随注射药物时间的延长而增高。结论 99Tcm HL91能够选择性地浓集于缺血缺氧的脑组织中 ,清除延缓 ,可用于急性脑卒中缺血半暗带的探测。
Objective To observe the distribution of 99Tcm 4,9 dinitro 3,3,10,10 tetramethyldodecane 2, 11 diketone oxime (HL91) in brain tissue of focal cerebral ischemia model. Methods A total of 31 rat models with focal cerebral ischemia were established. The distribution of 99Tcm HL91 in normal rats and in the brain of animal models was studied. At the same time, autoradiography was performed on the brain of animal models. Results 99Tcm HL91 was mainly distributed in the liver, kidney and small intestine after intravenous injection. The radioactivity of normal brain tissue was lower. The ratio of mass radioactivity per unit mass of the main blood supply area (target area) of affected / contralateral middle cerebral artery was significantly higher than that of the control group, and gradually increased with time. In the animal model, the self-developed images of the brain showed that the radioactivity of the target area was significantly higher than that of the contralateral mirror image. After image analysis and data processing by the computer image analysis system, there was a significant difference in the net absorbance value between the target area and the non-target area The difference of target / non-target ratio in each phase was significant compared with the control group, and increased with the time of injection. Conclusion 99Tcm HL91 can selectively accumulate in the brain tissue of hypoxia and hypoxia, and its debridement is delayed. It can be used to detect the ischemic penumbra in acute stroke.