The cooling and heating load distribution of large area air-conditioned room such as "open" offices, shopping malls and waiting rooms is usually assumed to be even in air conditioning system design. However, it is not the case in reality, and a low efficient air conditioning system results from this assumption. A simulation and analysis of the cooling load distribution of an office building in Hong Kong with TRANSYS software is provided in this paper. A typical office is divided into 13 zones for simulation, including external zone, medial zone and internal zone in the north, the south, the east and the west respectively and a central zone, instead of 4 directional zone. The result shows there is much cooling load difference between each zone, and more attention should be paid to uneven indoor cooling and heating load distribution to further guide the design.