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目的 评价原发性肝癌根治性切除术后肝血管灌注化疗的疗效 ,探讨肝癌切除术后复发的预防途径。方法 经病理确认的肝癌 5 4例 ,其中 3 4例行根治性切除术后肝动脉或门静脉置管化疗 ,每 4周一个疗程 ,重复 3～ 6个疗程。 2 0例根治性切除术后无任何化疗作为对照组。结果 肝血管灌注化疗组与对照组相比 ,术后1年复发率分别为 2 9.4 %和 4 0 % ,3年复发率分别为 64 .7%和 75 % ,二者有显著差异 (P <0 .0 5 )。结论 肝癌切除术后肝血管灌注化疗能预防癌复发 ,以肝动脉灌注优于门静脉 ,但二者结合效果更理想。
Objective To evaluate the curative effect of hepatic vascular perfusion chemotherapy after radical resection of primary hepatocellular carcinoma (HCC) and to explore the preventive ways of recurrent hepatocellular carcinoma after resection. Methods Totally 54 cases of hepatocellular carcinoma were confirmed by pathology. Among them, 34 cases received radical hepatectomy or portal vein chemotherapy after radical resection. Each treatment was repeated every 4 weeks for 3 to 6 cycles. Twenty cases of radical resection without any chemotherapy as a control group. Results Compared with the control group, the recurrence rates at 1 year and 2 years after hepatic vascular perfusion chemotherapy were respectively 2. 9.4% and 40%. The 3-year recurrence rates were 64.7% and 75%, respectively, with significant difference (P < 0 .0 5). Conclusion Hepatic cancer chemotherapy after liver resection can prevent the recurrence of cancer. Hepatic artery perfusion is superior to portal vein, but the combined effect is better.