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本文应用放免法测定了58例肾脏病患者的血浆内皮素(ET)水平,结果显示肾脏病患者ET较正常人明量增高.其增高程度与BUN,Gr,K~+,MAP呈正相关关系.肾性高血压患者较原发性高血压患者明显增高,血液透析组较尿毒症非透析组差异非常显著.血透后ET水平下降.本文还探讨了肾脏病患者ET升高的原因及血液透析对ET的影响,提出ET作为内源性致损伤因子对肾脏病的发生、发展有重要作用.
In this paper, we measured the level of plasma endothelin (ET) in 58 patients with nephropathy by radioimmunoassay and found that the ET level in nephrotic patients was higher than that in normal people, and the level of ET was positively correlated with BUN, Gr, K ~ + and MAP. Patients with renal hypertension were significantly higher than patients with essential hypertension, hemodialysis group than uremia non-dialysis group, the difference is very significant.After hemodialysis ET level decreased.This article also explores the cause of ET in patients with kidney disease and hemodialysis On the impact of ET, proposed ET as an endogenous injury factor on the occurrence and development of kidney disease has an important role.