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目的探讨妊娠期高血压疾病患者胎盘组织中Endoglin的水平变化及其在妊娠期高血压病发病中的作用。方法运用免疫组化法检测71例妊娠期高血压疾病患者(实验组,其中妊娠期高血压25例,轻度子痫前期23例,重度子痫前期23例)及20例正常妊娠孕妇(对照组)胎盘组织中的Endoglin表达。结果妊娠期高血压疾病与对照组比较,胎盘组织中Endoglin表达明显升高(P<0.05)。妊娠期高血压、轻、重度子痫前期患者胎盘组织中Endoglin表达逐渐升高,各组间比较差异有显著性(P<0.05)。妊娠期高血压与对照组比较,胎盘组织中Endoglin表达强度略有升高趋势,但差异无统计学意义(P>0.05)。结论孕妇胎盘组织中Endoglin表达水平的变化与妊娠期高血压病的发病及病情发展有关。
Objective To investigate the changes of endoglin levels in placenta of hypertensive disorder complicating pregnancy and its role in the pathogenesis of hypertensive disorder complicating pregnancy. Methods Immunohistochemical method was used to detect 71 cases of hypertensive disorder complicating pregnancy (experimental group, 25 cases of gestational hypertension, 23 cases of mild preeclampsia, 23 cases of severe preeclampsia) and 20 normal pregnant women Group) Endoglin expression in placental tissue. Results Compared with the control group, the expression of Endoglin in placenta was significantly increased in gestational hypertension (P <0.05). The levels of Endoglin in gestational hypertension, mild and severe preeclampsia patients increased gradually, and there was significant difference between the groups (P <0.05). Compared with the control group, the expression of Endoglin in gestational hypertension increased slightly, but the difference was not statistically significant (P> 0.05). Conclusion The changes of endoglin expression in placenta of pregnant women are related to the pathogenesis and development of hypertensive disorder complicating pregnancy.