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在pH 3．6-5．0的HAc-NaAc缓冲溶液中,当丹参酮ⅡA磺酸钠(STSIIA)与La(Ⅲ)反应形成螯合物时,将引起溶液共振瑞利散射(RRS)显著增强,并出现新的RRS光谱,其最大RRS峰位于306 nm．在一定范围内STSIIA浓度与散射强度(ΔI)成正比,反应具有高灵敏度,对STSIIA的检出限(3σ／K)为82．12 ng·mL-1．考察了STSIIA与La(Ⅲ)的适宜反应条件、影响因素和分析化学性质,并基于STSIIA与La(Ⅲ)反应产物的RRS光谱,发展了一种简便、快速测定STSIIA的新方法,可用于合成STSIIA过程中产品的纯度分析和诺新康注射液中STSIIA含量的测定．还结合红外光谱、核磁共振光谱对螯合物的结构及RRS增强的原因进行了探讨．
When sodium tanshinone IIA sulfonate (STSIIA) reacts with La (III) to form a chelate in HAc-NaAc buffer solution at pH 3.6-5.0, it causes a significant enhancement of Resonance Rayleigh Scattering (RRS) , And a new RRS spectrum appeared with the maximum RRS peak at 306 nm. The STSIIA concentration was proportional to the scattering intensity (ΔI) within a certain range. The sensitivity of the reaction was high. The detection limit (3σ / K) of STSIIA was 82.12 ng · mL-1. The suitable reaction conditions, influencing factors and analytical chemistry properties of STSIIA and La (Ⅲ) were investigated. Based on the RRS spectra of STSIIA and La (Ⅲ) reaction products, a novel method for the simple and rapid determination of STSIIA was developed and used to synthesize Purity analysis of products during STSIIA and determination of STSIIA content in Novolin Tablets. In addition, the structure of chelate and the reasons for the enhancement of RRS were also discussed with infrared spectroscopy and nuclear magnetic resonance spectroscopy.