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目的：探讨药物联合音乐治疗慢性精神病患者精神衰退的临床疗效。方法将90例慢性精神病伴精神衰退患者随机分为两组，每组45例，两组均予以常规抗精神病药物治疗及常规护理，研究组在此基础上联合音乐治疗，观察15周。治疗前后采用护士用住院病人观察量表评定患者的精神衰退状况。结果治疗后两组护士用住院病人观察量表积极因素评分均较治疗前显著升高，消极因素评分显著下降，研究组病情总估计评分显著升高（P＜0．01）；治疗前两组护士用住院病人观察量表评分比较差异无显著性（P＞0．05），治疗后研究组积极因素及病情总估计评分显著高于对照组（P＜0．01），消极因素评分显著低于对照组（P＜0．01）。结论药物联合音乐治疗能有效延缓慢性精神病患者的精神衰退进程，显著优于单纯应用药物治疗。“,”Objective To explore the clinical efficacy of drug combined with mu-sical therapy for mental deterioration of chronic psychotic .Methods Ninety chronic psychotics with men-tal deterioration were randomly divided into two groups of 45 ones each ,both groups received routine anti-psychotic treatment and nursing ,research group was plus musical therapy for 15 weeks .Mental deteriora-tion conditions were assessed with the Nurses’ Observation Scale for Inpatient Evaluation (NOSIE) before and after treatment .Results After treatment the NOSIE positive factor score of both groups heightened more significantly compared with pre-treatment and negative lowered ,and total score of patient′s condition hightened in reseach group (P 0 .05) ,after treatment positive factor and total assess score were significantly higher in research than con-trol group (P<0 .01) negative was lower (P<0 .01) .Conclusion Drug combined with musical therapy could effectively delay the process of mental deterioration of chronic psychotics compared with single drug treatment .