帕金森病 (PD)是一种常见的老年性中枢神经系统的退行性疾病 ,其主要病理变化是中脑黑质和黑质纹状体通路多巴胺能神经元的变性和丢失。目前 ,人们对PD的发病机制仍未明确 ,但越来越多的研究表明PD的发生是遗传易感性与外环境因素共同作用的结果 ,并且选择性多巴胺能神经元的损 Parkinson’s disease (PD) is a common degenerative disease of the senile CNS and its major pathological change is the degeneration and loss of dopaminergic neurons in the substantia nigra and nigrostriatal pathway. At present, the pathogenesis of PD remains unclear, but more and more studies have shown that the occurrence of PD is the result of the combination of genetic susceptibility and environmental factors, and the loss of selective dopaminergic neurons