目的:探讨惊恐障碍与多巴胺β羟化酶(dopamine-β-hydroxylase，DβH)和去甲肾上腺素转运体(norepinephrine transporter，NET)基因多态性的关系。方法:采用DSM-Ⅳ轴Ⅰ结构式临床访谈选取139例惊恐障碍患者(惊恐障碍组)和196例正常健康对照(对照组)。采用imLDRTM多重单核苷酸多态性(single nucleotide polymorphism，SNP)分型试剂盒对所有样本进行6个SNP位点分型，采用SPSS 16.0和PLINK比较等位基因频率及基因型分布差异。结果:(1)惊恐障碍组在NET rs5569多态性上携带G等位基因(76.3%)高于正常对照组(68.4%)，携带A等位基因(23.7%)少于对照组(31.6%)，差异有统计学意义(χn 2＝4.986，n OR＝0.67，95%n CI＝0.47~0.95，n P0.05)。(2)加性模型显示惊恐障碍组与正常对照组在NET rs5569多态性各基因型上差异有统计学意义(n OR＝0.68，95%n CI＝0.48~0.96，n P0.05)。n 结论:DβH和NET基因多态性与惊恐障碍可能不存在关联。“,”Objective:To explore the association between dopamine-β-hydroxylase (DβH), norepinephrine transporter (NET) gene polymorphisms and panic disorder(PD).Methods:The structured clinical interview for the diagnostic and statistical manual of mental disorders fourth edition (DSM-Ⅳ) axis Ⅰ disorders was administered by trained clinical psychiatrist, 139 patients with PD(PD group) and 196 healthy controls(control group) were enrolled in the study.Single nucleotide polymorphism(SNP) genotyping was performed using an improved multiplex ligation detection reaction technique.SPSS 16.0 and PLINK softwares were used to compare the allele frequency and genotype distribution.Results:(1)Compared with control group, PD group carried more G allele(76.3% n vs 68.4%) and fewer A allele(23.7% n vs 31.6%) in NET rs5569, and the difference was significant(χn 2=4.986, n OR=0.67, 95%n CI: 0.47-0.95, n P0.05). (2)The additive model of NET rs5569 showed a association with PD (n OR=0.68, 95%n CI: 0.48-0.96, n P0.05).n Conclusion:The present study indicates that there is no significant association of DβH and NET gene polymorphisms with PD.