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目的探讨鼠神经生长因子(NGF)联合单唾液酸四己糖神经节苷脂(GMI)治疗新生儿缺氧缺血性脑病(HIE)的临床疗效及其对患儿C反应蛋白(CRP)的影响。方法选取厦门市妇幼保健院2015年1月—2016年6月收治的HIE患儿80例,根据随机数字表法分为对照组和观察组,各40例。患儿入院后均给予常规对症治疗,对照组患儿给予GMI治疗,观察组患儿在对照组基础上给予NGF治疗,两组患儿均持续治疗10 d。比较两组患儿的临床疗效、临床症状及体征改善时间及治疗前后行为神经评分量表(NBNA)评分、CRP水平。结果观察组患儿临床疗效优于对照组(P<0.05)。观察组患儿意识、吸吮能力、肌张力及原始反射改善时间短于对照组(P<0.05)。治疗前,两组患儿NBNA评分及CRP水平比较,差异无统计学意义(P>0.05);治疗后,观察组患儿NBNA评分高于对照组,CRP水平低于对照组(P<0.05)。两组患儿治疗后NBNA评分高于治疗前,CRP水平低于治疗前(P<0.05)。结论采用NGF联合GMI治疗新生儿HIE的临床疗效确切,可有效改善患儿的临床症状,促进神经功能恢复,抑制炎性反应。
Objective To investigate the clinical efficacy of NGF and monosialotetrahexosyl gangliosides (GMI) in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE) and its effect on the expression of C-reactive protein (CRP) influences. Methods Eighty children with HIE admitted to Xiamen Maternal and Child Health Hospital from January 2015 to June 2016 were randomly divided into control group and observation group according to random number table method, 40 cases in each group. Children admitted to hospital were given conventional symptomatic treatment, control group of children given GMI treatment, observation group of children in the control group on the basis of NGF treatment, both groups of children were treated for 10 days. The clinical efficacy, clinical symptoms and signs of improvement and the score of neurological score (NBNA) before and after treatment were compared between the two groups, CRP level. Results The clinical efficacy of observation group was better than that of control group (P <0.05). The observation group children awareness, sucking ability, muscle tone and time to improve the original reflection shorter than the control group (P <0.05). Before treatment, there was no significant difference in NBNA score and CRP level between the two groups (P> 0.05). After treatment, NBNA score in the observation group was higher than that in the control group, CRP level was lower than the control group (P <0.05) . The NBNA score of the two groups was higher than that before treatment, and the CRP level was lower than before treatment (P <0.05). Conclusions The clinical efficacy of NGF combined with GMI in the treatment of neonatal HIE is definite. It can effectively improve the clinical symptoms, promote the recovery of neurological function and inhibit the inflammatory reaction.