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目的了解重庆市2012年健康人群脊髓灰质炎(脊灰)中和抗体(Neutralizing Antibody,NA)水平,为维持无脊灰状态提供参考。方法抽取南岸区、大足区、奉节县的部分健康人群,应用细胞中和试验法检测脊灰NA。结果在检测的629名健康人群血清标本中,脊灰Ⅰ、Ⅱ、Ⅲ型NA阳性率分别为93.31%、96.34%和91.88%;NA几何平均滴度(Geometric Mean Titer,GMT)分别为1∶77.86、1∶76.50和1∶26.41。各年龄组人群Ⅰ型脊灰NA阳性率差异无统计学意义(2=5.314,P>0.05),Ⅱ、Ⅲ型脊灰NA阳性率差异均有统计学意义(2Ⅱ=19.312,2Ⅲ=14.093;P均<0.05);各年龄组人群Ⅰ、Ⅱ、Ⅲ型脊灰NA GMT差异均有统计学意义(FⅠ=34.054,FⅡ=36.481,FⅢ=21.08;P均<0.05)。三个区(县)人群Ⅰ、Ⅲ型脊灰NA阳性率差异均有统计学意义(2Ⅰ=13.866,2Ⅲ=8.545;P均<0.05),Ⅱ型脊灰NA阳性率差异无统计学意义(2Ⅱ=3.307,P>0.05);三个区(县)人群Ⅰ、Ⅱ、Ⅲ型脊灰NA GMT差异均无统计学意义(FⅠ=2.528,FⅡ=1.328,FⅢ=2.583;P均>0.05)。NA水平总趋势随着年龄增长而递减。结论重庆市健康人群脊灰NA水平可以维持无脊灰状态。
Objective To understand the levels of polio (Neutralizing Antibody, NA) in healthy population in Chongqing in 2012 and provide a reference for maintaining polio-free status. Methods Some healthy people in Nanan District, Dazu District and Fengjie County were collected and the pollen NA was detected by cell neutralization assay. Results Among the 629 healthy human serum samples tested, the positive rates of type Ⅰ, Ⅱ and Ⅲ NA were 93.31%, 96.34% and 91.88%, respectively. The Geometric Mean Titer (GMT) of NA were 1: 77.86, 1:76.50 and 1:26.41. There was no significant difference in the positive rate of type Ⅰmicroglobulin among all age groups (2 = 5.314, P> 0.05). There was significant difference in the positive rate of NA between type Ⅱ and type Ⅲ polio (2Ⅱ = 19.312,2Ⅲ = 14.093; P <0.05). There was significant difference in NA GMT of type Ⅰ, Ⅱ and Ⅲ among all age groups (F Ⅰ = 34.054, FⅡ = 36.481, F Ⅲ = 21.08; P all <0.05). The positive rates of NA of type Ⅰ and type Ⅲ of poliomyelitis among the three districts (counties) were all statistically significant (2Ⅰ = 13.866, 2Ⅲ = 8.545; P <0.05), but there was no significant difference in the positive rate of NA Ⅱ 2Ⅱ = 3.307, P> 0.05). There was no significant difference in NA GMT of Ⅰ, Ⅱ and Ⅲ poliomyelitis among the three districts (FⅠ = 2.528, FⅡ = 1.328, FⅢ = 2.583; . The general trend of NA levels decreases with age. Conclusion The level of poliomyelin NA in healthy population in Chongqing can maintain polio-free status.