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目前对骨髓异常增生综合征(MDS)的治疗主要包括支持治疗,激素治疗,抗白血病治疗,分化诱导剂和生物效应调节剂的应用.后者主要包括细胞因子和生长因子的应用.细胞因子干扰素在恶性疾病中的作用机理仍然存在许多争论.临床研究表明,干扰素具有抗增殖作用和诱导分化作用.在慢性粒细胞白血病,α_2-干扰素不论在体外还是在体内都有抑制细胞遗传异常的作用.随后又报道了干扰素,使MDS部分缓解.有一例患者,在用α-干扰素治疗34天后,δ三型体异常完全消失,表明恶性造血细胞克隆已根除.干扰素的副作用尚不能低估,它的使用限于临床情况良好的“年轻”患者.γ-干扰素不仅能减少原始细胞的克隆形成,诱导白血病细
At present, the treatment of myelodysplastic syndrome (MDS) mainly includes the application of supportive therapy, hormone therapy, anti-leukemia therapy, differentiation inducer and biological effect regulator, which mainly includes the application of cytokines and growth factors. There are still many controversies about the mechanism of action in malignant diseases.Clinical studies have shown that interferon has anti-proliferative effects and induction of differentiation.In chronic myeloid leukemia, α 2-interferon inhibits cytogenetic abnormalities both in vitro and in vivo .And then reported the interferon, MDS partial response.One patient in the treatment of α-interferon for 34 days, δ trisomy completely disappeared, indicating that malignant hematopoietic cell clonality has been eradicated. The side effects of interferon It can not be overestimated that its use is limited to patients with well-established “younger.” Interferon-gamma not only reduces clonogenic formation of primary cells and induces leukemia