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越来越多的研究资料表明破骨细胞分化因子/护骨因子配基可能是唯一能够直接诱导破骨细胞分化的细胞因子,其功能性受体RANK位于前破骨细胞及破骨细胞表面,介导了细胸分化信号的传导。破骨细胞生成抑制因子/护骨因子是破骨细胞分化因子/护骨因子配基的假活性受体,能竞争性抑制破骨细胸分化因子/护骨因子配基与RANK的结合,从而抑制破骨细胞的生成及功能。本文综述了破骨细胞生成抑制因子和分化因子的发现、结构和功能,并探讨了二者之间的相互作用机制。
More and more research data show that osteoclast differentiation factor / chelator gene ligand may be the only direct induction of osteoclast differentiation cytokines, the functional receptor RANK in the former osteoclast and osteoclast surface, Mediated the conduction of fine-breed differentiation signals. Osteoclast inhibitory factor / osteoprotegerin is a pseudo-active receptor of osteoclast differentiation factor / osteoprotegerin ligand that competitively inhibits the binding of osteoclast differentiation factor / osteoprotegerin ligand to RANK, thereby Inhibit osteoclastogenesis and function. This article reviews the discovery, structure and function of osteoclastogenesis inhibitory and differentiation factors and explores the mechanisms of their interaction.