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目的:评价伊来西胺添加用药治疗难治性癫痫的临床疗效及安全性。方法:采用开放性自身对照临床试验,对48例难治性癫痫加用伊来西胺,观察加用前后总发作频率的变化,并计算总体有效率,同时观察其不良反应。结果:伊来西胺治疗前8周(基线期)与治疗后24周总发作频率相比较,治疗前总平均发作频率为每周23.38次,治疗后总平均发作频率是每周7.88次。经配对样本t检验,伊来西胺治疗后总发作频率变化具有显著差异(P<0.05),添加伊来西胺治疗难治性癫痫总体有效率为72.91%。不良反应以胃肠道症状为主,绝大部分轻微,可自行消失。结论:伊来西胺添加治疗难治性癫痫疗效显著,安全性好。
OBJECTIVE: To evaluate the clinical efficacy and safety of ilemexamine in the treatment of refractory epilepsy. Methods: In an open controlled clinical trial, 48 patients with refractory epilepsy were enrolled in the study. The changes of total seizure frequency were observed before and after the addition. The total effective rate was calculated and the adverse reactions were observed. Results: The mean seizure frequency before treatment was 23.38 times per week, and the average frequency of seizures was 7.88 times per week after the treatment of elisidine for 8 weeks (baseline) and 24 weeks after treatment. The paired sample t-test showed that the frequency of total seizures was significantly different after treatment with imatinib (P <0.05). The overall effective rate of treatment with esomeprazole was 72.91%. Adverse reactions mainly to gastrointestinal symptoms, the vast majority of minor, can disappear. Conclusion: The treatment of refractory epilepsy with Yi Xian Xi amine is effective and safe.