目的：观察负荷量苯妥英对脑卒中后难治性癫的疗效。方法：脑卒中后难治性癫患者５５例，苯妥英钠首日剂量２０ｍｇ／（ｋｇ·ｄ），第２、３天为１０ｍｇ／（ｋｇ·ｄ），而后改为７ｍｇ／（ｋｇ·ｄ）。监测血药浓度。随访时间为１～２年，平均１５．６月。结果：有效２６例，有效率４７％。用药后３６例脑电性放电次数减少，１１例脑电基本节律恢复正常，无慢性中毒反应，７例出现急性神经系统毒性反应。结论：苯妥英钠负荷疗法对脑卒中后难治性癫有一定疗效 Objective: To observe the effect of phenytoin on post-stroke refractory epilepsy. Methods: Fifty-five patients with post-stroke refractory epilepsy were treated with phenytoin 20mg / (kg · d) on the first day, 10mg / (kg · d) on the 2nd and 3rd days, and then changed to 7mg / (kg · d ). Monitor blood concentration. Follow-up time was 1 to 2 years, an average of 15.6 months. Results: Effective in 26 cases, effective rate of 47%. 36 cases of electroencephalogram after discharge reduced the number of electrical discharge, 11 cases of normal brain electrical rhythm returned to normal, no chronic toxic reactions, 7 cases of acute nervous system toxicity. Conclusion: Phenytoin loading therapy has some curative effect on post-stroke refractory epilepsy