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目的 :通过检测不同类型冠心病 (CHD)患者血浆组织因子 (TF)和组织因子途径抑制物 (TFPI)水平变化 ,探讨其在CHD发病过程中的作用。方法 :以酶联免疫吸附测定法测定CHD患者血浆中TF和TFPI抗原水平。结果 :不稳定型心绞痛 (UAP)和急性心肌梗死 (AMI)患者的血浆TF和TFPI水平与正常对照者和稳定型心绞痛 (SAP)患者相比均有显著性增高 (P <0 .0 5 ) ,以AMI患者尤为明显 (P <0 .0 1) ;UAP和AMI患者的TF PI/TF比值显著降低 (P <0 .0 5 ) ,而SAP患者的上述指标与正常对照者相比 ,其差异均无显著性意义 (P >0 .0 5 )。结论 :UAP和AMI患者TFPI/TF系统失衡 ,标志高凝状态的存在 ;TF和TFPI在这两种类型CHD的发病机制中可能起着重要的作用
Objective: To explore the role of TFPI in the pathogenesis of CHD by detecting the changes of plasma tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in patients with different types of coronary heart disease (CHD). Methods: The levels of TF and TFPI antigen in plasma of patients with CHD were determined by enzyme linked immunosorbent assay. Results: Plasma TF and TFPI levels in patients with unstable angina pectoris (UAP) and acute myocardial infarction (AMI) were significantly higher than those in patients with stable angina pectoris (SAP) (P <0.05) , Especially in patients with AMI (P <0.01). The TF / TF ratio in patients with AMI and UAP was significantly lower (P <0.05), while those in patients with SAP were significantly lower than those in normal controls There was no significant difference (P> 0.05). Conclusion: The imbalance of TFPI / TF in UAP and AMI patients indicates the existence of hypercoagulable state. TF and TFPI may play important roles in the pathogenesis of these two types of CHD