藿香 Agastache rugosa 全草的甲醇提取物对依托泊苷诱导的 U937细胞株的凋亡显示强抑制作用。作者从该植物中分离和鉴定了2个具细胞凋亡抑制作用的新木脂素类化合物 agastinol(1)和 agastenol(2)。风干的藿香全草于室温下用甲醇渗滤3周,除去溶剂后残留物加水稀释,再用乙酸乙酯提取,乙酸乙酯提取物浓缩后得黑色浆状物,其经硅胶柱层析,氯仿-甲醇梯度洗脱,活性部位经 Sephadex LH-20柱层析,甲醇-水 Musk Agastache rugosa’s methanol extract showed a strong inhibitory effect on etoposide-induced apoptosis in U937 cell lines. The authors isolated and identified 2 new lignanoids agastinol (1) and agastenol (2) with apoptosis inhibition. The air-dried Musk whole plant was diafiltered with methanol at room temperature for 3 weeks. After the solvent was removed, the residue was diluted with water and extracted with ethyl acetate. The ethyl acetate extract was concentrated to give a black syrup which was subjected to silica gel column chromatography. , Chloroform-methanol gradient elution, active fractions were chromatographed on Sephadex LH-20, methanol-water