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幽门螺杆菌(Hp)根除治疗对Hp阳性的早期低度胃MALT淋巴瘤及部分高度恶性胃MALT淋巴瘤常有明显疗效,甚至对Hp阴性者及胃外MALT淋巴瘤也有一定的疗效。API2-MALT1融合基因、C3三倍体、副蛋白等可能成为疗效的预测新指标。大部分获得组织学完全缓解的病人,IgH重排基因持续存在,因此在评价抗Hp治疗对MALT淋巴瘤疗效时可能应结合肿瘤的单克隆B细胞增殖是否消退。
Helicobacter pylori (Hp) eradication treatment of Hp-positive early low-grade gastric MALT lymphoma and some highly malignant gastric MALT lymphoma often have significant effect, even in Hp-negative and extra-gastric MALT lymphoma have a certain effect. API2-MALT1 fusion gene, C3 triploid, paraprotein may become a new indicator of therapeutic efficacy. Most patients with histologically complete remission persist with IgH rearrangement genes and therefore may have diminished the proliferation of tumor-bearing monoclonal B-cells in evaluating the efficacy of anti-Hp therapy for MALT lymphoma.