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目的 研究原发性肝细胞性肝癌 (HCC)中表皮生长因子受体 (EGFR)及C ErbB 2蛋白的表达 ,并分析其意义。方法 用免疫组化ABC法 ,检测 32例HCC中EGFR及C ErbB 2蛋白的表达 ,对照组为正常肝组织 8例、肝硬化组织11例。结果 EGFR阳性率在HCC组、肝硬化组、正常肝组织组间无显著性差异 (P >0 .0 5 )。癌旁肝组织阳性率与正常肝组、肝硬化组、HCC组无显著性差异 (P >0 .0 5 )。C ErbB 2阳性率在HCC组、肝硬化组、正常肝组织组间存在显著性差异 (P <0 .0 5 )。癌旁肝组织中的阳性率与HCC组存在显著性差异 (P <0 .0 5 ) ,与肝硬化组不存在显著性差异 (P >0 .0 5 )。C ErbB 2在病理分级高分化组和低分化组间、高分化组和未分化组间存在显著性差异 (P <0 .0 5 ) ,而在低分化组和未分组间不存在显著性差异 (P >0 .0 5 )。结论 EGFR与HCC的发生、发展无关。C ErbB 2在HCC发生、发展过程中发挥作用 ,具有一定的判断HCC恶性程度的意义。
Objective To study the expression of epidermal growth factor receptor (EGFR) and C ErbB 2 in primary hepatocellular carcinoma (HCC) and to analyze its significance. Methods Immunohistochemical ABC method was used to detect the expression of EGFR and C ErbB 2 in 32 cases of HCC. The control group consisted of 8 normal liver tissues and 11 cirrhotic tissues. Results The positive rate of EGFR in HCC group, cirrhosis group and normal liver tissue group had no significant difference (P> 0.05). The positive rate of paracancer liver tissue had no significant difference with normal liver, cirrhosis and HCC (P> 0.05). The positive rate of ErbB 2 in HCC, cirrhosis and normal liver tissue was significantly different (P <0.05). There was a significant difference between the positive rate of para-cancerous liver tissue and HCC group (P <0.05), but there was no significant difference with that of cirrhosis group (P> 0.05). There was significant difference between well-differentiated group and undifferentiated group (P <0.05) between ErbB 2 highly differentiated group and poorly differentiated group, but no significant difference between poorly differentiated group and non-differentiated group (P> 0.05). Conclusion EGFR has nothing to do with the occurrence and development of HCC. C ErbB 2 plays a role in the occurrence and development of HCC, and has certain significance in judging the malignant degree of HCC.