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目的:探讨心肌能量代谢药物曲美他嗪(TMZ)对老年高血压患者左心室肥厚及左室功能的影响。方法:64例老年高血压患者被随机分为治疗组和对照组。对照组采用常规治疗方法,治疗组在常规治疗基础上加用曲美他嗪(TMZ)口服(20mg,3次/日),疗程为6个月。记录并比较治疗前后超声检查左心室重量指数(LVMI)及左心室射血分数(LVEF)的结果。结果:对照组LVMI无明显变化,而曲美他嗪治疗组LVMI降低(P<0.05)。对照组LVEF略增加,但差异无统计学意义(P>0.05);曲美他嗪治疗组LVEF则明显改善(P<0.05)。两组间LVMI及LVEF差异比较均有统计学意义(P<0.05)。结论:在常规降压治疗基础上加用曲美他嗪,能进一步逆转左心室肥厚及改善左心室收缩功能。
Objective: To investigate the effect of myocardial energy metabolism drug trimetazidine (TMZ) on left ventricular hypertrophy and left ventricular function in elderly patients with hypertension. Methods: 64 elderly hypertensive patients were randomly divided into treatment group and control group. The control group was treated by routine treatment. The treatment group was treated with trimetazidine (TMZ) orally (20mg, 3 times / day) on the basis of routine treatment for 6 months. The results of left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) before and after treatment were recorded and compared. Results: There was no significant change in LVMI in the control group, but LVMI in the trimetazidine treatment group was decreased (P <0.05). LVEF in control group increased slightly, but the difference was not statistically significant (P> 0.05); LVEF in trimetazidine treatment group was significantly improved (P <0.05). LVMI and LVEF differences between the two groups were statistically significant (P <0.05). Conclusion: The combination of trimetazidine with conventional antihypertensive therapy can further reverse left ventricular hypertrophy and improve left ventricular systolic function.