多年来,在细胞遗传学研究的基础上,已证实许多慢性粒细胞白血病(CML)病人的骨髓和外周血有正常造血细胞。如一些CML病人有部分骨髓细胞呈Ph阴性,大批CML病人经传统治疗后约1/4病例骨髓细胞部分显示正常细胞中期分裂象。应用强烈化疗或干扰素治疗后也使部分病例出现细胞遗传学上正常的骨髓细胞或Ph阴性细胞,得到部分或完全恢复。 For many years, based on cytogenetics studies, it has been demonstrated that many patients with chronic myeloid leukemia (CML) have normal hematopoietic cells in the bone marrow and peripheral blood. For example, some CML patients have some bone marrow cells Ph negative, a large number of CML patients after conventional treatment of about 1/4 cases of bone marrow cells showed normal part of the metaphase. Partial or complete recovery of cytogenetically normal bone marrow cells or Ph-negative cells also occurred in some cases after intensive chemotherapy or interferon treatment.