Whiteflies (Bemisia tabaci) are polyphagous invasive hemipteran insects that cause serious losses of important crops by directly feeding on phloem sap and transmitting pathogenic viruses.These insects have emerged as a major threat to global agriculture and food security.Chemically synthesized insecticides are currently the only option to control whiteflies,but the ability of whiteflies to evolve resistance against insecticides has made the management of these insects very difficult.Natural host-plant resistance against whiteflies identified in some crop plants has not been exploited to a great extent.Genetic engineering approaches,such as transgenics and RNA interference (RNAi),are potentially useful for the control of whiteflies.Transgenic plants harboring insecticidal toxins/lectins developed via nuclear or chloroplast transformation are a promising vehicle for whitefly control.Double-stranded RNAs (dsRNAs) of several insect genes,delivered either through microinjection into the insect body cavity or orally via an artificial diet and transiently or stably expressed in transgenic plants,have controlled whiteflies in model plants and in some crops at the laboratory level,but not at the field level.In this review,we highlight the merits and demerits of each delivery method along with strategies for sustained delivery of dsRNAs via fungal entomopathogen/endosymbiont or nontransgenic RNAi approaches,foliar sprays,root absorption or nanocarriers as well as the factors affecting efficient RNAi and their biosafety issues.Genome sequencing and transcriptome studies of whitefly species are facilitating the selection of appropriate genes for RNAi and gene-editing technology for the efficient and resilient management of whiteflies and their transmitted viruses.