众所周知,有些药物特别是皮质类固醇激素和抗疟药可引起肌病,但至今未见常规抗结核药引起肌病的报导。现报告1例利福平引起严重近端肌病。患者女性,44岁。1980年肺结核复发,胸片见新鲜空洞,痰直接涂片未发现抗酸杆菌,但经Lwenstein-Jensen培养获得分枝杆菌菌落。用链霉素、利福平、异烟肼和乙胺丁醇治疗。4周后上臂、大腿近端肌肉进行性软弱无力,不能单独站立。无感觉倒错、感觉缺失和肌肉疼痛。面部及眼部肌肉未受影响,无提示重症肌无力的咽下困难或异常疲劳感。物理检查除受累部位近端肌肉软弱无力外,其他均正常。受患部位上述情况在大腿较上臂更显著,且伴有对称性近端肌 It is well-known that some drugs, especially corticosteroids and antimalarials, can cause myopathy, but so far none of the conventional anti-TB drugs has reported myopathy. A case of rifampicin is reported to cause severe proximal myopathy. Female patient, 44 years old. Pulmonary tuberculosis recurred in 1980, with fresh voids in the chest and no acid-fast bacilli in sputum smear, but mycobacterial colonies were obtained by Lwenstein-Jensen culture. With streptomycin, rifampin, isoniazid and ethambutol treatment. 4 weeks after the upper arm, proximal thigh muscle weakness, can not stand alone. No feeling inverted, feeling loss and muscle ache. Facial and eye muscles are unaffected, with no indication of myasthenia gravis dysphagia or abnormal fatigue. Physical examination except the affected part of the proximal muscle weakness, the other are normal. Affected parts of the above situation in the thigh more than the upper arm more prominent, and accompanied by symmetrical proximal muscle