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Three arylamide-bridged biscoumarin derivatives 1-3 have been designed and prepared. Compounds 1 and 2 are induced by the intramolecular N?H…O and N·H…F hydrogen bonding to possess a helical conformation,and 3 is induced to have an extended conformation. A comparison of their absorption and fluorescent spectra in a variety of solvents of a wide range of polarity with those of control compound 4 reveals that,for foldamers 1 and 2,the intramolecular hydrogen bonding and the helical conformations exist in most solvents,but do not exist or are very weak in DMF and DMSO.
Three arylamide-bridged biscoumarin derivatives 1-3 have been designed and prepared. Compounds 1 and 2 are induced by the intramolecular N? H ... O and N? H ... F hydrogen bonding to possess a helical conformation, and 3 is induced to have an extended conformation. A comparison of their absorption and fluorescent spectra in a variety of solvents of a wide range of polarity with those of control compound 4 reveals that, for foldamers 1 and 2, the intramolecular hydrogen bonding and the helical conformations exist in most solvents, but do not exist or are very weak in DMF and DMSO.