0引言胰腺癌是一种恶性程度极高的消化系统恶性肿瘤,其发病隐匿,进展快,预后差。大约80%的患者确诊时往往伴有局部的侵犯或者转移,5年生存率仅为4%。胰腺癌死亡率居高不下的主要原因是临床早期诊断的困难性、缺乏有效的临床治疗方法以及对胰腺癌发生发展机制尚未完全 0 Introduction Pancreatic cancer is a malignant malignancy of digestive system, its occult onset, rapid progress, the prognosis is poor. Approximately 80% of patients are diagnosed with localized invasion or metastasis, and the 5-year survival rate is only 4%. The main reason for the high mortality rate of pancreatic cancer is the difficulty of early clinical diagnosis, the lack of effective clinical treatment methods and the incomplete mechanism of development and progression of pancreatic cancer