目的比较食物对两种桂利嗪胶囊(A和B)人体生物利用度的影响。方法用HPLC紫外检测法测定健康受试者分别在禁食及餐后一次口服50mg桂利嗪胶囊A或B后血清药物浓度。结果胶囊A的Cmax 及AUC不受食物影响 ,胶囊B的吸收受食物影响 ,禁食后的Cmax 和AUC显著低于餐后的Cmax 和AUC。结论胶囊A的制剂优于胶囊B的制剂 ,其人体生物利用度不受食物影响 Objective To compare the effects of food on the bioavailability of two cinnarizine capsules (A and B). Methods Serum drug concentrations of healthy subjects after fasting and 50mg cinnarizine capsule A or B orally once were determined by HPLC UV detection. Results The Cmax and AUC of capsule A were not affected by food. The absorption of capsule B was influenced by food. The Cmax and AUC after fasting were significantly lower than the postprandial Cmax and AUC. Conclusion Capsule A is superior to capsule B formulation in that its bioavailability is unaffected by food