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目的:探讨谷胱苷肽硫转移酶M1(GSTM1)和T1(GSTT1)基因多态性与四川北部地区汉族人群肺癌易感性的关系。方法:采用病例对照研究和聚合酶链式反应(PCR)技术检测四川北部地区肺癌病人125例和健康对照组125例中GSTM1(-)和GSTT1(-)的频率,评价两基因型及两基因的交互作用与肺癌易感性的关系。结果:GSTM1(-)在肺癌组和对照组分布频率分别为58.4%和56.8%,单因素回归分析未见统计学差异(OR=1.06,95%CI:0.639-1.757,P=0.822);GSTT1(-)在肺癌组和对照组分布频率分别为45.6%和44.8%,单因素回归分析未见统计学差异(OR=0.968,95%CI:0.588-1.593,P=0.899),GSTM1(-)和GSTT1(-)联合并未增加肺癌风险(OR=1.084,95%CI:0.536-2.192,P=0.823)。结论:GSTM1及GSTT1各基因型单独或联合作用都不是四川北部地区汉族人群肺癌的风险因素。
Objective: To investigate the relationship between polymorphisms of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) and susceptibility to lung cancer in Han population of northern Sichuan. Methods: The frequency of GSTM1 (-) and GSTT1 (-) in 125 patients with lung cancer and 125 healthy controls in northern Sichuan were detected by case-control study and polymerase chain reaction (PCR) Interaction with lung cancer susceptibility. Results: The distribution frequencies of GSTM1 (-) in lung cancer group and control group were 58.4% and 56.8%, respectively. There was no significant difference between the two groups (OR = 1.06,95% CI: 0.639-1.757, P = 0.822) (-) was 45.6% and 44.8% in lung cancer group and control group respectively. There was no significant difference between the two groups (OR = 0.968,95% CI: 0.588-1.593, P = 0.899) Combined with GSTT1 (-) did not increase the risk of lung cancer (OR = 1.084, 95% CI: 0.536-2.192, P = 0.823). Conclusion: The genotypes of GSTM1 and GSTT1, individually or in combination, are not risk factors for lung cancer in Han population of northern Sichuan.