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糖尿病肾病(DN)是世界范围内导致终末期肾病的重要原因之一,目前仍缺乏十分有效的特异性疗法。深入研究DN的病理机制及研发有效的DN损伤标志物是目前研究的焦点与热点。随着对DN发病机制研究的不断深入,多种致病因子及信号通路得以发现,并研发出针对DN疾病过程中多种致病因子的拮抗剂及调节剂,这些新开发的药物在动物实验及部分小样本的临床研究中表现出良好的疗效,本文就DN最新药物的临床与实验研究进展作一综述。
Diabetic nephropathy (DN) is one of the most important causes of end-stage renal disease in the world. Currently, there are still no effective and specific therapies. In-depth study of the pathological mechanism of DN and the development of effective DN damage markers is the focus of research and hot spots. With the deepening of the research on the pathogenesis of DN, a variety of pathogenic factors and signaling pathways have been found, and developed a variety of antagonists and regulators of various pathogenic factors in the process of DN disease. These newly developed drugs in animal experiments And some small samples of clinical studies have shown good efficacy, this article on the latest drug DN clinical and experimental research are reviewed.