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目的分析胰岛素与西格列汀联合用药治疗老年Ⅱ型糖尿病的临床疗效,为临床合理用药提供参考依据。方法研究对象为本院2015年3月-2016年3月收治的100例老年Ⅱ型糖尿病患者。随机分为研究组50例和对照组50例。对照组患者使用胰岛素联合二甲双胍治疗,研究组采用胰岛素联合西格列汀治疗;观察对比两组患者治疗前后体质量指数(BMI)、低血糖发生频次,治疗后空腹血糖(FPG)、餐后2 h血糖(2h PG)、糖化血红蛋白(Hb Alc)、胰岛素用量及不良反应发生率。结果研究组治疗后2h PG(9.50±4.60)mmol/L、Hb Alc(7.19±0.79)%、胰岛素用量(42.80±11.53)U比对照组更有优势,差异有统计学意义(P<0.05);研究组不良反应发生率(6.00%)低于对照组(24.00%),差异有统计学意义(P<0.05);研究组治疗后BMI(28.20±2.89)kg/m~2、低血糖发生频次(5.30±0.21)次均优于对照组,差异有统计学意义(P<0.05)。结论对老年Ⅱ型糖尿病患者,使用胰岛素、西格列汀联合药物治疗效果较理想,能够减少患者临床上使用胰岛素总量。
Objective To analyze the clinical efficacy of combination therapy of insulin and sitagliptin in the treatment of senile type Ⅱ diabetes, and provide a reference for clinical rational drug use. Methods The subjects were 100 elderly patients with type 2 diabetes who were admitted to our hospital from March 2015 to March 2016. Randomly divided into study group 50 cases and control group 50 cases. The patients in the control group were treated with insulin and metformin. The study group was treated with insulin and sitagliptin. Before and after treatment, BMI, frequency of hypoglycemia, fasting plasma glucose (FPG), postprandial 2 h blood glucose (2h PG), glycosylated hemoglobin (Hb Alc), insulin dosage and the incidence of adverse reactions. Results The levels of PG (9.50 ± 4.60) mmol / L, Hb Alc (7.19 ± 0.79)% and insulin (42.80 ± 11.53) U in the study group were more superior than those in the control group at 2h after treatment ; The incidence of adverse reactions in study group was lower than that in control group (6.00% vs 24.00%, P <0.05); the BMI in study group was (28.20 ± 2.89) kg / m 2 and the incidence of hypoglycemia Frequency (5.30 ± 0.21) times were better than the control group, the difference was statistically significant (P <0.05). Conclusion The elderly with type 2 diabetes, the use of insulin, sitagliptin combined drug treatment is more satisfactory, can reduce the clinical use of insulin in patients with total.