甘露醇是甘露糖的还原物,临床上常用作渗透性利尿剂,但有的病人应用后可发生高渗透性肾病, 严重者导致急性肾功能衰竭(ARF).我院自1982年以来见到甘露醇性肾病8例,现报告如下。临床资料一.一般资料:男6例,女2例。年龄25～65岁,平均48岁。原发病为脑外伤3例,脑溢血2例,右侧听神经鞘瘤1例,流脑2例。8例均大剂量使用了20%甘露醇,其中1250～1500ml/日,2～5天的5例,750～1000ml/日,3～7天的3例。急性肾功能衰竭发生时间:6例发生于用药后2～5 Mannitol is a mannose reductant, clinically used as osmotic diuretics, but some patients may occur after the application of hypertonic renal disease, severe acute renal failure (ARF) .From 1982 to see our hospital Mannitol nephropathy in 8 cases, are as follows. Clinical data I. General information: 6 males and 2 females. Aged 25 to 65 years old, average 48 years old. The primary disease was 3 cases of traumatic brain injury, 2 cases of cerebral hemorrhage, 1 case of schwannoma on the right side and 2 cases of meningitis. In 8 cases, 20% mannitol was used in high dose, including 1250 ~ 1500ml / day, 5 cases in 2 ~ 5 days, 750 ~ 1000ml / day and 3 cases in 3 ~ 7 days. Acute renal failure occurred time: 6 cases occurred after treatment 2 ~ 5