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目的:观察急性冠状动脉综合征患者外周血单核细胞过氧化物酶增殖体激活受体γ的表达及其临床意义。方法:选择急性冠状动脉综合征患者67例,20例排除冠心病的成年人为对照组;测定外周血单核细胞过氧化物酶增殖体激活受体γ的表达。结果:急性冠状动脉综合征患者外周血单核细胞过氧化物酶增殖体激活受体γ的表达较对照组低(P<0.05),其中急性心肌梗死患者较不稳定心绞痛患者表达更低(P<0.05)。结论:急性冠状动脉综合征患者过氧化物酶体增殖激活受体γ的表达较对照组降低,外周血单核细胞过氧化物酶增殖体激活受体γ表达水平可反映冠心病患者病情严重程度。
Objective: To observe the expression of peroxisome proliferator activated receptor gamma in peripheral blood mononuclear cells in patients with acute coronary syndrome and its clinical significance. Methods: 67 patients with acute coronary syndrome and 20 adults with coronary heart disease were selected as the control group. The expression of peroxisome proliferator activated receptor γ in peripheral blood mononuclear cells was measured. Results: The expression of peroxisome proliferator activated receptor γ in peripheral blood mononuclear cells of patients with acute coronary syndrome was lower than that of the control group (P <0.05), and was lower in patients with acute myocardial infarction than in patients with unstable angina (P <0.05). Conclusion: The expression of peroxisome proliferator - activated receptor γ in patients with acute coronary syndrome is lower than that in control group. The expression level of peroxisome proliferator - activated receptor γ in peripheral blood mononuclear cells can reflect the severity of coronary heart disease .