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目的探讨洋地黄毒甙（ＤＴ）体内抗肿瘤活性及时常用化疗药５－氟尿嘧啶（５－ＦＵ）和环磷酰胺（ＣＴＸ）的增效作用。方法 应用小鼠移植性肿瘤模型，观察药物对小鼠生命延长率或肿瘤抑制率的影响。在可耐受的剂量（０．１ｍｇ／ｋｇ·ｄ－１，ｉｐ）下治疗小鼠腹水瘤ＥＡＣ，Ｈ２２，Ｐ３８８及实体瘤Ｓ１８０，Ｕ１４。结果 对腹水瘤无对抗作用，对实体瘤有一定抑制作用，抑瘤率分别为３４．６％，３５．１％。ＤＴ与５－ＦＵ（２００ｍｇ／ｋｇ·ｄ－１×１，ｉｐ）合用能显著提高５－ＦＵ对腹水瘤小鼠的生命延长率，分别达到５９．３％，７７．４％和９３．２％；与轻度抑瘤作用剂量（２０ｍｇ／ｋｇ·ｄ－１×２，ｉｐ）的ＣＴＸ合用，对实体瘤的抑瘤活性高于单独给药组，抑瘤率分别为７８．８％，８０．８％。结论 ＤＴ和５－ＦＵ或ＣＴＸ合用具有增强疗效的作用，毒性无明显相加。
Objective To investigate the anti-tumor activity of digoxigenin (DT) in vivo and the synergistic effects of 5-fluorouracil (5-FU) and cyclophosphamide (CTX). Methods Mouse transplanted tumor model was used to observe the effect of drugs on the life extension rate or tumor inhibition rate in mice. Mouse ascites tumors EAC, H22, P388 and solid tumors S180, U14 were treated at tolerable doses (0.1 mg / kg · d-1, ip). The results of non-confluent ascites tumor, solid tumors have a certain inhibitory effect, tumor inhibition rates were 34.6%, 35.1%. DT combined with 5-FU (200mg / kg · d-1 × 1, ip) could significantly prolong the life span of 5-FU-treated mice by 59.3%, 77.4% and 93.2% respectively %. The combination of CTX with mild anti-tumor dose (20mg / kg · d-1 × 2, ip) had higher antitumor activity on solid tumors than that of the single drug alone. The tumor inhibition rates were 78.8% 80.8%. Conclusion Combination of DT and 5-FU or CTX has the effect of enhancing the curative effect, and the toxicity does not add up obviously.