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建立用高效液相色谱仪测定血浆中补骨脂内酯浓度专一且灵敏的方法。经胃肠道给药的补骨脂内酯血药浓度 -时间曲线呈现“双峰”现象 ,表明补骨脂内酯的体内代谢存在较明显的肠 -肝循环过程
Establish a specific and sensitive method for determining the concentration of psoralen in plasma by high performance liquid chromatography. The concentration-time curve of psoralen lactone in the gastrointestinal tract showed a “double peak” phenomenon, indicating that the body metabolism of psoralen lactone is more obvious than that of the enterohepatic circulation.