论文部分内容阅读
以年龄和工龄作为配比因素，采用流行病学频数配比的方法，在某化纤厂选择45岁以下，工龄在10年以上的76名二硫化碳（CS2）作业工人作为接触组；在同一工厂内选择相同年龄和工龄范围、曾经接触过CS2但现在已停止CS2接触5年以上的33名工人作为干预组；从未接触过CS2的23名工人作为对照组。对以上对象进行了流行病学横断面调查表明：接触组在1：10、1：Z0、1：4O、1：804种不同抗体滴度下，血清热应激蛋白70（HSP70）抗体阳性检出率均高于对照组（P＜0．05）；血清HSP70抗体阳性检出率均与CS2接触有关系，并随着抗体滴度的增加，比值比（OR）也随之增大，说明低浓度CS2接触是血清HSP70阳性检出率升高的独立危险因素。提示HSP70可作为低浓度CS2接触致心血管系统毒性的生物标志物。
Taking the age and length of service as the matching factor, 76 CS2 workers aged below 45 and over 10 years in a chemical fiber factory were selected as the contact group according to the epidemiological frequency ratio. In the same factory, A total of 33 workers of the same age and seniority who had been in contact with CS2 but now stopped CS2 exposure for more than five years were selected as the intervention group. Twenty-three workers who had never been exposed to CS2 were selected as the control group. The epidemiological cross-sectional survey of the above subjects showed that in the exposure group, the serum heat stress protein 70 (HSP70) antibody positive test was detected at 804 different antibody titers of 1: 10, 1: Z0, 1: 4O and 1: (P <0.05). The positive rate of serum HSP70 antibody was correlated with CS2 exposure, and with the increase of antibody titer, the odds ratio (OR) also increased Low concentrations of CS2 exposure is an independent risk factor for the increased detection of serum HSP70. It suggested that HSP70 could be used as a biomarker of cardiovascular toxicity induced by low concentration of CS2.