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由于现有控制疟疾措施的效果下降,发展安全有效的疫苗已成为控制疟疾的主要希望。业已证实,环子孢子蛋白(CSP)在疟疾保护性免疫中起重要作用。本文报道用包皮垢分枝杆菌(M.smegmatis)和牛结核杆菌卡介菌(M.bovis-BCG)作为宿主细胞表达CSP的一种新方法。
As the effectiveness of existing malaria control measures declines, the development of safe and effective vaccines has become the main hope for malaria control. It has been demonstrated that circumsporozoite protein (CSP) plays an important role in protective immunity against malaria. Here we report a new method to express CSP using M.smegmatis and M. bovis-BCG as host cells.