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目的:探讨国产两性霉素B对恶性血液病并发肺部真菌感染的疗效和安全性。方法:对河南省肿瘤医院血液科2001年12月~2005年12月期间经微生物学和临床资料证实的38例肺部真菌感染患者,随机分为2组(传统给药组即逐步加量组和改良给药组即起始足量组)接受国产两性霉素B治疗,观察2组疗效及不良反应。结果:38例应用国产两性霉素B患者中有3例因严重药物不良反应停药,其余35例患者比较显示改良给药组达显效时间短于传统给药组,2组间总体疗效及不良反应差异无统计学意义。结论:一开始即给足够剂量的国产两性霉素B治疗恶性血液病并发肺部真菌感染达显效时间短于逐渐加药的给药方法,其不良反应及总体疗效与后者差异无统计学意义。
Objective: To investigate the efficacy and safety of domestic amphotericin B in patients with hematologic malignancies complicated by pulmonary fungal infection. Methods: Thirty-eight patients with pulmonary fungal infection confirmed by microbiology and clinical data from December 2001 to December 2005 in Department of Hematology, Cancer Hospital of Henan Province were randomly divided into two groups (traditional dose group, And the modified drug group that is the initial enough group) received domestic amphotericin B treatment, two groups were observed efficacy and adverse reactions. Results: Among the 38 patients with domestic amphotericin B, 3 patients discontinued due to serious adverse drug reactions. The remaining 35 patients showed that the effective time was shorter in the modified drug delivery group than in the traditional drug delivery group. The overall efficacy and adverse effects There was no significant difference in response. CONCLUSION: The initial dose of homemade amphotericin B for treating hematologic malignancies complicated by pulmonary fungal infection was significantly shorter than the dosing method gradually, and the adverse reactions and overall efficacy were not statistically different from the latter .