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作者应用光镜,免疫荧光和电镜研究40例 IgA 肾病,其中13例仅有系膜 IgA 沉积而无 IgG 及 IgM 沉积。免疫荧光检查此13例中12例有 C_3沉积,且其分布与IgA 相同,13例(100%)均有系膜λ轻链,10例(77%)有 K 轻链,单克隆抗体显示λ免疫荧光为13例(100%),K 免疫荧光8例(61.5%),λ和κ轻链的系膜免疫荧光类型与α重链相似。IgA 肾病血清 IgA 总量,κ-IgA 及λ-IgA 均较高,κ/λ比值倒置,且比健康人有显著减低(p<0.001)。在此研究中已确定含 IgA 的λ轻链占优势。最近研究表明 IgA 肾病是一种免疫复合
The authors used light microscopy, immunofluorescence and electron microscopy of 40 cases of IgA nephropathy, of which only 13 mesangial IgA deposition without IgG and IgM deposition. Immunofluorescence showed that there were 12 cases of C_3 deposition in 13 of 13 cases with the same distribution of IgA, 13 cases (100%) had mesangial lambda light chain and 10 cases (77%) had K light chain, and the monoclonal antibody showed λ Thirteen (100%) were immunofluorescence and eight (61.5%) were K immunofluorescence. The type of mesangial immunofluorescence of the lambda and kappa light chains was similar to that of the alpha heavy chain. IgA nephropathy serum total IgA, κ-IgA and λ-IgA were higher, κ / λ ratio inversion, and significantly lower than healthy people (p <0.001). In this study it has been determined that lambda light chains containing IgA predominate. Recent studies have shown that IgA nephropathy is an immune complex