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目的探讨甲氨蝶呤联合米非司酮治疗异位妊娠临床效果。方法选取我院在2012年1月~2014年1月收治的84例异位妊娠患者作为研究对象,根据治疗方法的不同,将其分为研究组和对照组(每组42例),研究组采用甲氨蝶呤联合米非司酮治疗,对照组单纯应用米非司酮,对比两组患者的治疗效果及不良发应发生率。结果研究组的治愈率、治疗2w症状消失率,治疗3周包块缩小率,均显著高于对照组(P<0.05);研究组患者的住院时间、HCG水平降至正常时间,均明显短于对照组,P<0.05,差异有统计学意义;研究组的不良反应发生率为11.9%,对照组为9.5%,组间比较无统计学意义(P>0.05)。结论临床治疗异位妊娠,采用米非司酮联合甲氨蝶呤治疗,具有起效快、疗效好、操作简便、不良反应少等优点,是理想的异位妊娠保守疗法。
Objective To investigate the clinical effect of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. Methods Eighty-four patients with ectopic pregnancy admitted to our hospital from January 2012 to January 2014 were selected as study subjects. According to the different treatment methods, they were divided into study group and control group (42 cases in each group), study group Methotrexate combined with mifepristone treatment, simple control group mifepristone, the treatment of two groups compared the efficacy and incidence of adverse reactions. Results In the study group, the cure rate, the rate of disappearance after 2 weeks of treatment and the shrinkage rate of the mass at 3 weeks after treatment were significantly higher than those in the control group (P <0.05). The hospitalization time and HCG level in the study group decreased to normal time In the control group, P <0.05, the difference was statistically significant. The incidence of adverse reactions in the study group was 11.9% and in the control group was 9.5%, there was no significant difference between the two groups (P> 0.05). Conclusion Clinical treatment of ectopic pregnancy, the use of mifepristone combined with methotrexate treatment, with fast onset, good curative effect, simple operation, fewer adverse reactions, is the ideal conservative treatment of ectopic pregnancy.