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目的：研究门脉高压性胃粘膜病变（ＰＨＧ）的实质及其与血清中ＴＮＦ、ＥＴ的浓度变化的关系。方法：对３０例门脉高压性胃粘膜病变患者和１５例门脉高压症非胃粘膜病变（ＮＰＨＧ）患者的胃粘膜进行光镜、透射电镜观察，同时应用放免法检测二组血清中ＴＮＦ、ＥＴ的浓度。结果：门脉高压时胃粘膜微循环障碍是ＰＨＧ形成的实质；门脉高压病患者血清中ＴＮＦ、ＥＴ的浓度变化与ＰＨＧ的发生、发展呈正相关；比较二组血清中ＴＮＦ、ＥＴ浓度差异有显著性（Ｐ＜０．０１）。结论：门脉高压时胃粘膜微循环变化包括有细胞机制和免疫反应二个方面的参与。
Objective: To study the essence of portal hypertension gastric mucosal lesions (PHG) and its relationship with changes of serum TNF and ET concentrations. Methods: The gastric mucosa of 30 patients with portal hypertension gastric mucosal lesions and 15 patients with non-gastric mucosal lesions of portal hypertension (NPHG) were observed by light microscopy and transmission electron microscope. The levels of TNF, Concentration of ET. Results: Gastric mucosal microcirculation disturbance was the essence of PHG formation in portal hypertension. The changes of serum TNF and ET concentrations in patients with portal hypertension were positively correlated with the occurrence and development of PHG. The differences of serum TNF and ET concentrations Significance (P <0.01). Conclusion: The changes of gastric mucosal microcirculation in portal hypertension include the involvement of cellular mechanism and immune response.